Charmila has appeared in over 50 films, working with renowned directors and actors. Some of her notable films include:

and gained significant popularity through her collaboration with director Bharathan and actor Mohanlal.

A track from her Tamil-Malayalam crossover work that remains a fan favourite . Television and Other Media

Charmila entered the Malayalam film industry during a transitional period. The late 1980s saw the decline of pure "mythological" films and the rise of family dramas, slapstick comedies, and socio-political thrillers. Charmila fit perfectly into the new archetype of the "girl next door."